Common additives in soft drink include caffeine, aspartame, benzoic acid, and acesulfame-K. Quality control demands to determine these additives. HPLC has been used for this analysis. An increase in the number of samples to be measured requires high-throughput analysis.

In order to meet this requirement, Jasco applied the extreme high pressure liquid chromatography system (X-LC) equipped with a 2 um packing column to the analysis of these additives using the high-pressure gradient method.