ISOLUTE SLE+ Supported Liquid Extraction plates and columns offer an efficient alternative to traditional liquid-liquid extraction (LLE) for bioanalytical sample preparation, providing high analyte recoveries, no emulsion formation, and significantly reduced sample preparation.

This application note describes the extraction of the anaesthetic agent Propofol from whole blood prior to GC/MS analysis. Effective and efficient ISOLUTE SLE+ protocols optimized for the 400 uL and 1 mL capacity column format are described.