The Biotage ISOLUTE Si-Propylsulfonic Acid (SCX-2) belongs to a class of strong supported acids. As a bound sulfonic acid, it has a natural propensity to bind alkali and some transition metal group metals, which means that it can be used as a scavenger for metals with a +I or +II oxidation state, such as Na, K, Li, also Pd, Rh, and Ru. SCX-2 is typically used as a metal scavenger when the target product is not basic, to avoid the obvious acid/ base product binding interactions with the scavenger. If the product is basic then Si-Tiol, SI TMT, MP-TMT or Si-Trisamine may be utilized instead. The advantage of using SCX-2 as a polymer supported acid is that it eliminates traditional laborious work-up steps.

Other uses:

• Scavenge (removing) amines and other bases from solution
• As an acid catalyst in reactions
• Catch and release purification of amines, to facilitate either solvent switching or amine purification